Understand B12 Absorption To Learn B12 Def

11 Mar, 2021

Dr. Rajesh Bollam

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Understand B12 Absorption to Learn B12 Def
Mouth
R (in saliva)
B12-protein (P)
Stomach
Chief cells->HCl+pepsin->B12+P
B12 binds R
Parietal cells->IF
Pancreas->enzyme to duodenum
B12-R->B12+R (via panc enz)
Binds IF
Ilium
B12-IF->cubulin receptor
B12-TC in blood to cells
Mouth =
Bad diet
Stomach =
Gastric bypass
Atrophic gastritis (no chief cells to make acid)
PPIs
Pernicious anemia (no IF)
Chronic pancreatitis (no enz to release B12 from R)
Jejunum
Bacterial overgrowth
Ilium
Crohn's (no cells that absorb B12)
Genetic ⬇️TC
**** When ever u find Vitamin b12 deficiency just supplementing B12 does not end the problem try to find out cause and address the same ****

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